Cargando…

Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions

A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice. The mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Wenhan, Garrett, Caroline, Dombert, Benjamin, Soura, Violetta, Banks, Gareth, Fisher, Elizabeth M. C., van der Brug, Marcel P., Hafezparast, Majid
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000974/ https://www.ncbi.nlm.nih.gov/pubmed/20889981 http://dx.doi.org/10.1074/jbc.M110.178087

Ejemplares similares

The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease
por: El-Kadi, Ali Morsi, et al.
Publicado: (2010)

Cytoplasmic Dynein and Dynactin Are Required for the Transport of Microtubules into the Axon
por: Ahmad, Fridoon J., et al.
Publicado: (1998)

Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein
por: Hammesfahr, Björn, et al.
Publicado: (2012)

Cytoplasmic dynein heavy chain: the servant of many masters
por: Schiavo, Giampietro, et al.
Publicado: (2013)

Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts
por: Kuta, Anna, et al.
Publicado: (2010)

Correction: Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts
por: Kuta, Anna, et al.
Publicado: (2010)

Dynactin drives dynein without microtubule binding
por: Williams, Ruth
Publicado: (2007)

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
por: Lee, In-Gyun, et al.
Publicado: (2018)

Dynein, Dynactin, and Kinesin II's Interaction with Microtubules Is Regulated during Bidirectional Organelle Transport
por: Reese, Eric L., et al.
Publicado: (2000)

Cytoplasmic dynein nomenclature
por: Pfister, K. Kevin, et al.
Publicado: (2005)

A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization
por: Helfand, Brian T., et al.
Publicado: (2002)

Characterization of the p22 Subunit of Dynactin Reveals the Localization of Cytoplasmic Dynein and Dynactin to the Midbody of Dividing Cells
por: Karki, Sher, et al.
Publicado: (1998)

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1
por: Twelvetrees, Alison E., et al.
Publicado: (2016)

ZW10 Helps Recruit Dynactin and Dynein to the Kinetochore
por: Starr, Daniel A., et al.
Publicado: (1998)

Structural organization of the dynein-dynactin complex bound to microtubules
por: Chowdhury, Saikat, et al.
Publicado: (2015)

A mathematical understanding of how cytoplasmic dynein walks on microtubules
por: Trott, L., et al.
Publicado: (2018)

The mammalian dynein/dynactin complex is a strong opponent to kinesin in a tug-of-war competition
por: Belyy, Vladislav, et al.
Publicado: (2016)

Kinesin and dynein use distinct mechanisms to bypass obstacles
por: Ferro, Luke S, et al.
Publicado: (2019)

Formation of Spindle Poles by Dynein/Dynactin-Dependent Transport of Numa
por: Merdes, Andreas, et al.
Publicado: (2000)

Distinct cell cycle–dependent roles for dynactin and dynein at centrosomes
por: Quintyne, Nicholas J., et al.
Publicado: (2002)

Autoregulatory Mechanism for Dynactin Control of Processive and Diffusive Dynein Transport
por: Tripathy, Suvranta K., et al.
Publicado: (2014)

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein
Publicado: (1991)

Dynein Intermediate Chain Mediated Dynein–Dynactin Interaction Is Required for Interphase Microtubule Organization and Centrosome Replication and Separation inDictyostelium
por: Ma, Shuo, et al.
Publicado: (1999)

Ciliary Dyneins and Dynein Related Ciliopathies
por: Antony, Dinu, et al.
Publicado: (2021)

Impact-Free Measurement of Microtubule Rotations on Kinesin and Cytoplasmic-Dynein Coated Surfaces
por: Mitra, Aniruddha, et al.
Publicado: (2015)

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs
por: Dix, Carly I., et al.
Publicado: (2013)

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3
por: Schroeder, Courtney M., et al.
Publicado: (2016)

Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin
por: Elshenawy, Mohamed M., et al.
Publicado: (2019)

Lis1 activates dynein motility by modulating its pairing with dynactin
por: Elshenawy, Mohamed M., et al.
Publicado: (2020)

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin
por: d’Amico, Ennio A., et al.
Publicado: (2022)

Conditional Deletion of Cytoplasmic Dynein Heavy Chain in Postnatal Photoreceptors
por: Dahl, Tiffanie M., et al.
Publicado: (2021)

Review: Cytoplasmic dynein motors in photoreceptors
por: Dahl, Tiffanie M., et al.
Publicado: (2021)

Genetic Analysis of the Cytoplasmic Dynein Subunit Families
por: Pfister, K. Kevin, et al.
Publicado: (2006)

Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
por: Jara, Kayla A, et al.
Publicado: (2022)

Transport of fungal RAB11 secretory vesicles involves myosin-5, dynein/dynactin/p25, and kinesin-1 and is independent of kinesin-3
por: Peñalva, Miguel A., et al.
Publicado: (2017)

Reconstitution of dynein transport to the microtubule plus end by kinesin
por: Roberts, Anthony J, et al.
Publicado: (2014)

An Unconventional Kinesin and Cytoplasmic Dynein Are Responsible for Interkinetic Nuclear Migration in Neural Stem Cells
por: Tsai, Jin-Wu, et al.
Publicado: (2010)

Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued
Publicado: (1995)

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function
por: Tai, Chin-Yin, et al.
Publicado: (2002)

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction
por: Zhang, Jun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_p1ta4fi40npt2rsi5fgd9i7tfn