Cargando…
Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs
Next-generation DNA sequencing technology was used to score >100 000 mutations resulting from exposure of a nucleic acid template to a mutagenic dNTP analog during a single pass of a DNA polymerase. An RNA template of known secondary structure was reverse transcribed in the presence of 8-oxo-dGTP...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001061/ https://www.ncbi.nlm.nih.gov/pubmed/20693528 http://dx.doi.org/10.1093/nar/gkq685 |