Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases

CAG repeats occur predominantly in the coding regions of human genes, which suggests their functional importance. In some genes, these sequences can undergo pathogenic expansions leading to neurodegenerative polyglutamine (poly-Q) diseases. The mutant transcripts containing expanded CAG repeats poss...

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Detalles Bibliográficos
Autores principales: Kiliszek, Agnieszka, Kierzek, Ryszard, Krzyzosiak, Wlodzimierz J., Rypniewski, Wojciech
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001072/
https://www.ncbi.nlm.nih.gov/pubmed/20702420
http://dx.doi.org/10.1093/nar/gkq700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001072/
https://www.ncbi.nlm.nih.gov/pubmed/20702420
http://dx.doi.org/10.1093/nar/gkq700

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