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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
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| Formato: | Texto |
| Lenguaje: | English |
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The Royal Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001308/ https://www.ncbi.nlm.nih.gov/pubmed/21115525 http://dx.doi.org/10.1098/rstb.2010.0276 |