Accurate Protein Structure Annotation through Competitive Diffusion of Enzymatic Functions over a Network of Local Evolutionary Similarities

High-throughput Structural Genomics yields many new protein structures without known molecular function. This study aims to uncover these missing annotations by globally comparing select functional residues across the structural proteome. First, Evolutionary Trace Annotation, or ETA, identifies whic...

Descripción completa

Detalles Bibliográficos
Autores principales: Venner, Eric, Lisewski, Andreas Martin, Erdin, Serkan, Ward, R. Matthew, Amin, Shivas R., Lichtarge, Olivier
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001439/
https://www.ncbi.nlm.nih.gov/pubmed/21179190
http://dx.doi.org/10.1371/journal.pone.0014286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001439/
https://www.ncbi.nlm.nih.gov/pubmed/21179190
http://dx.doi.org/10.1371/journal.pone.0014286

Ejemplares similares