Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

BACKGROUND: Hypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the “angiogenic switch” during tumor progression. HIF-1α is often upregulated in tumors leading to more aggressive tumor growth and chemoresistance, therefo...

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Detalles Bibliográficos
Autores principales: Nardinocchi, Lavinia, Pantisano, Valentina, Puca, Rosa, Porru, Manuela, Aiello, Aurora, Grasselli, Annalisa, Leonetti, Carlo, Safran, Michal, Rechavi, Gideon, Givol, David, Farsetti, Antonella, D'Orazi, Gabriella
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001454/
https://www.ncbi.nlm.nih.gov/pubmed/21179202
http://dx.doi.org/10.1371/journal.pone.0015048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001454/
https://www.ncbi.nlm.nih.gov/pubmed/21179202
http://dx.doi.org/10.1371/journal.pone.0015048

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