Fiber Type Conversion by PGC-1α Activates Lysosomal and Autophagosomal Biogenesis in Both Unaffected and Pompe Skeletal Muscle

PGC-1α is a transcriptional co-activator that plays a central role in the regulation of energy metabolism. Our interest in this protein was driven by its ability to promote muscle remodeling. Conversion from fast glycolytic to slow oxidative fibers seemed a promising therapeutic approach in Pompe di...

Descripción completa

Detalles Bibliográficos
Autores principales: Takikita, Shoichi, Schreiner, Cynthia, Baum, Rebecca, Xie, Tao, Ralston, Evelyn, Plotz, Paul H., Raben, Nina
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001465/
https://www.ncbi.nlm.nih.gov/pubmed/21179212
http://dx.doi.org/10.1371/journal.pone.0015239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001465/
https://www.ncbi.nlm.nih.gov/pubmed/21179212
http://dx.doi.org/10.1371/journal.pone.0015239

Ejemplares similares