Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

Maintaining undifferentiated mouse embryonic stem cell (mESC) culture has been a major challenge as mESCs cultured in Leukemia Inhibitory Factor (LIF) conditions exhibit spontaneous differentiation, fluctuating expression of pluripotency genes, and genes of specialized cells. Here we show that, in s...

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Detalles Bibliográficos
Autores principales: Chowdhury, Farhan, Li, Yanzhen, Poh, Yeh-Chuin, Yokohama-Tamaki, Tamaki, Wang, Ning, Tanaka, Tetsuya S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001487/
https://www.ncbi.nlm.nih.gov/pubmed/21179449
http://dx.doi.org/10.1371/journal.pone.0015655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001487/
https://www.ncbi.nlm.nih.gov/pubmed/21179449
http://dx.doi.org/10.1371/journal.pone.0015655

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