Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells

BACKGROUND: Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been well understood and no clear mechanism of resistance has been elucidated to explain limited efficacy of HDACis in clinical trials. M...

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Detalles Bibliográficos
Autores principales: Brazelle, William, Kreahling, Jenny M., Gemmer, Jennifer, Ma, Yihong, Cress, W. Douglas, Haura, Eric, Altiok, Soner
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001870/
https://www.ncbi.nlm.nih.gov/pubmed/21179472
http://dx.doi.org/10.1371/journal.pone.0014335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001870/
https://www.ncbi.nlm.nih.gov/pubmed/21179472
http://dx.doi.org/10.1371/journal.pone.0014335

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