Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol

A bis-imine (prepared via a new FeCl(3)-based method) in combination with CoCl(2) facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine.

Detalles Bibliográficos
Autores principales: Arunkumar, K, Reddy, M Appi, Kumar, T Sravan, Kumar, B Vijaya, Chandrasekhar, K B, Kumar, P Rajender, Pal, Manojit
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002020/
https://www.ncbi.nlm.nih.gov/pubmed/21160565
http://dx.doi.org/10.3762/bjoc.6.134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002020/
https://www.ncbi.nlm.nih.gov/pubmed/21160565
http://dx.doi.org/10.3762/bjoc.6.134

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