Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol

A bis-imine (prepared via a new FeCl(3)-based method) in combination with CoCl(2) facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine.

Detalles Bibliográficos
Autores principales: Arunkumar, K, Reddy, M Appi, Kumar, T Sravan, Kumar, B Vijaya, Chandrasekhar, K B, Kumar, P Rajender, Pal, Manojit
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002020/
https://www.ncbi.nlm.nih.gov/pubmed/21160565
http://dx.doi.org/10.3762/bjoc.6.134
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author Arunkumar, K
Reddy, M Appi
Kumar, T Sravan
Kumar, B Vijaya
Chandrasekhar, K B
Kumar, P Rajender
Pal, Manojit
author_facet Arunkumar, K
Reddy, M Appi
Kumar, T Sravan
Kumar, B Vijaya
Chandrasekhar, K B
Kumar, P Rajender
Pal, Manojit
author_sort Arunkumar, K
collection PubMed
description A bis-imine (prepared via a new FeCl(3)-based method) in combination with CoCl(2) facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine.
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spelling pubmed-30020202010-12-15 Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol Arunkumar, K Reddy, M Appi Kumar, T Sravan Kumar, B Vijaya Chandrasekhar, K B Kumar, P Rajender Pal, Manojit Beilstein J Org Chem Letter A bis-imine (prepared via a new FeCl(3)-based method) in combination with CoCl(2) facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine. Beilstein-Institut 2010-12-10 /pmc/articles/PMC3002020/ /pubmed/21160565 http://dx.doi.org/10.3762/bjoc.6.134 Text en Copyright © 2010, Arunkumar et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Arunkumar, K
Reddy, M Appi
Kumar, T Sravan
Kumar, B Vijaya
Chandrasekhar, K B
Kumar, P Rajender
Pal, Manojit
Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
title Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
title_full Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
title_fullStr Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
title_full_unstemmed Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
title_short Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
title_sort achiral bis-imine in combination with cocl(2): a remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002020/
https://www.ncbi.nlm.nih.gov/pubmed/21160565
http://dx.doi.org/10.3762/bjoc.6.134
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