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Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
A bis-imine (prepared via a new FeCl(3)-based method) in combination with CoCl(2) facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine.
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002020/ https://www.ncbi.nlm.nih.gov/pubmed/21160565 http://dx.doi.org/10.3762/bjoc.6.134 |