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Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells
BACKGROUND: Prostaglandin E(2 )(PGE(2)), an arachidonic acid metabolite converted by cyclooxygenase-2 (COX-2), plays important roles in the regulation of endothelial functions in response to bacterial infection. The enzymatic activity of COX-2 can be down-regulated by heme oxygenase-1 (HO-1) inducti...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002338/ https://www.ncbi.nlm.nih.gov/pubmed/21118574 http://dx.doi.org/10.1186/1742-2094-7-86 |