Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site

Polycystin (PC)1 and PC2 are membrane proteins implicated in autosomal dominant polycystic kidney disease. A physiologically relevant cleavage at PC1's G protein-coupled receptor proteolytic site (GPS) occurs early in the secretory pathway. Our results suggest that PC2 increases both PC1 GPS cl...

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Detalles Bibliográficos
Autores principales: Chapin, Hannah C., Rajendran, Vanathy, Caplan, Michael J.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002387/
https://www.ncbi.nlm.nih.gov/pubmed/20980620
http://dx.doi.org/10.1091/mbc.E10-05-0407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002387/
https://www.ncbi.nlm.nih.gov/pubmed/20980620
http://dx.doi.org/10.1091/mbc.E10-05-0407

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