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Uptake of Aggregating Transthyretin by Fat Body in a Drosophila Model for TTR-Associated Amyloidosis

BACKGROUND: A functional link has been established between the severe neurodegenerative disorder Familial amyloidotic polyneuropathy and the enhanced propensity of the plasma protein transthyretin (TTR) to form aggregates in patients with single point mutations in the TTR gene. Previous work has led...

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Detalles Bibliográficos
Autores principales: Pokrzywa, Malgorzata, Dacklin, Ingrid, Vestling, Monika, Hultmark, Dan, Lundgren, Erik, Cantera, Rafael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002944/
https://www.ncbi.nlm.nih.gov/pubmed/21179560
http://dx.doi.org/10.1371/journal.pone.0014343