Binding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies

A molecular docking study was carried out on 28 compounds belonging to 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs using Glide, FlexX and GOLD programs and the X-ray crystallographic structures of the quadruple mutant (1J3K:pdb) and wild type (1J3I:pdb) Plasmodium falciparum dihydrofolat...

Descripción completa

Detalles Bibliográficos
Autores principales: Adane, L., Bharatam, P. V.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003165/
https://www.ncbi.nlm.nih.gov/pubmed/21188041
http://dx.doi.org/10.4103/0250-474X.70478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003165/
https://www.ncbi.nlm.nih.gov/pubmed/21188041
http://dx.doi.org/10.4103/0250-474X.70478

Ejemplares similares