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Binding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies

A molecular docking study was carried out on 28 compounds belonging to 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs using Glide, FlexX and GOLD programs and the X-ray crystallographic structures of the quadruple mutant (1J3K:pdb) and wild type (1J3I:pdb) Plasmodium falciparum dihydrofolat...

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Detalles Bibliográficos
Autores principales:	Adane, L., Bharatam, P. V.
Formato:	Texto
Lenguaje:	English
Publicado:	Medknow Publications 2010
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003165/ https://www.ncbi.nlm.nih.gov/pubmed/21188041 http://dx.doi.org/10.4103/0250-474X.70478

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