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Rapid Liquid Chromatographic Method for the Determination of Roflumilast in the Presence of Degradation Products
A forced degradation study on roflumilast drug substance was conducted under the conditions of hydrolysis, oxidation, thermal and photolysis. The method was developed and optimized by analyzing forcefully degraded samples. The best separation was achieved on a Zorbax SB C18 1.8 µm column with 0.005...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003183/ https://www.ncbi.nlm.nih.gov/pubmed/21188058 http://dx.doi.org/10.4103/0250-474X.70496 |