Cargando…

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells

Store-operated calcium entry is essential for many signaling processes in nonexcitable cells. The best studied store-operated calcium current is the calcium release-activated calcium (CRAC) current in T-cells and mast cells, with Orai1 representing the essential pore forming subunit. Although it is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Madl, Josef, Weghuber, Julian, Fritsch, Reinhard, Derler, Isabella, Fahrner, Marc, Frischauf, Irene, Lackner, Barbara, Romanin, Christoph, Schütz, Gerhard J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003411/ https://www.ncbi.nlm.nih.gov/pubmed/20961852 http://dx.doi.org/10.1074/jbc.M110.177881

Ejemplares similares

Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating
por: Frischauf, Irene, et al.
Publicado: (2011)

The STIM1/Orai signaling machinery
por: Fahrner, Marc, et al.
Publicado: (2013)

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
por: Muik, Martin, et al.
Publicado: (2011)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
por: Derler, Isabella, et al.
Publicado: (2018)

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating
por: Bergsmann, Judith, et al.
Publicado: (2011)

Molecular mechanisms of STIM/Orai communication
por: Derler, Isabella, et al.
Publicado: (2016)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
por: Derler, Isabella, et al.
Publicado: (2013)

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
por: Derler, Isabella, et al.
Publicado: (2013)

The many states of STIM1
por: Fahrner, Marc, et al.
Publicado: (2021)

Communication between N terminus and loop2 tunes Orai activation
por: Fahrner, Marc, et al.
Publicado: (2018)

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
por: Tiffner, Adéla, et al.
Publicado: (2020)

Imaging of Mobile Long-lived Nanoplatforms in the Live Cell Plasma Membrane
por: Brameshuber, Mario, et al.
Publicado: (2010)

Orai1 Boosts SK3 Channel Activation
por: Tiffner, Adéla, et al.
Publicado: (2021)

Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner
por: Tiffner, Adéla, et al.
Publicado: (2021)

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
por: Yeung, Priscilla S-W, et al.
Publicado: (2023)

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
por: Maltan, Lena, et al.
Publicado: (2023)

The Orai Pore Opening Mechanism
por: Tiffner, Adéla, et al.
Publicado: (2021)

Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases
por: Han, Sejin, et al.
Publicado: (2010)

A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore
por: Yeung, Priscilla S-W, et al.
Publicado: (2020)

Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology
por: Tiffner, Adéla, et al.
Publicado: (2021)

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins
por: Keown, Jeremy R., et al.
Publicado: (2018)

Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly
por: Lu, Meng, et al.
Publicado: (2019)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

Orai channels: key players in Ca(2+) homeostasis
por: Sallinger, Matthias, et al.
Publicado: (2020)

Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics
por: Saldaño, Tadeo. E., et al.
Publicado: (2017)

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
por: Stathopulos, Peter B., et al.
Publicado: (2013)

Blockage of Store-Operated Ca(2+) Influx by Synta66 is Mediated by Direct Inhibition of the Ca(2+) Selective Orai1 Pore
por: Waldherr, Linda, et al.
Publicado: (2020)

Structures of translationally inactive mammalian ribosomes
por: Brown, Alan, et al.
Publicado: (2018)

Swing‐out opening of stromal interaction molecule 1
por: Horvath, Ferdinand, et al.
Publicado: (2023)

Structural basis for mammalian nucleotide sugar transport
por: Ahuja, Shivani, et al.
Publicado: (2019)

A New Homotetramer Hemoglobin in the Pulmonary Surfactant of Plateau Zokors (Myospalax Baileyi)
por: Li, Jimei, et al.
Publicado: (2022)

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Saponaro, Andrea, et al.
Publicado: (2018)

Transport Mechanism and pH Regulation of the Na(+)/H(+) Antiporter NhaA from Escherichia coli: AN ELECTROPHYSIOLOGICAL STUDY
por: Mager, Thomas, et al.
Publicado: (2011)

Drosophila melanogaster Myosin-18 Represents a Highly Divergent Motor with Actin Tethering Properties
por: Guzik-Lendrum, Stephanie, et al.
Publicado: (2011)

Recognition and Specificity Determinants of the Human Cbx Chromodomains
por: Kaustov, Lilia, et al.
Publicado: (2011)

Atomic Force Microscopy Studies Provide Direct Evidence for Dimerization of the HIV Restriction Factor APOBEC3G
por: Shlyakhtenko, Luda S., et al.
Publicado: (2011)

Oxidation State-dependent Protein-Protein Interactions in Disulfide Cascades
por: Mavridou, Despoina A. I., et al.
Publicado: (2011)

Timothy Mutation Disrupts the Link between Activation and Inactivation in Ca(V)1.2 Protein
por: Depil, Katrin, et al.
Publicado: (2011)

The NPH-II Helicase Displays Efficient DNA·RNA Helicase Activity and a Pronounced Purine Sequence Bias
por: Taylor, Sean David, et al.
Publicado: (2010)

Characterization of the Biochemical Properties and Biological Function of the Formin Homology Domains of Drosophila DAAM
por: Barkó, Szilvia, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_frn9qd35k1ssup3b637kj3ievq