RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

INTRODUCTION: Rat adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) feature bone loss and systemic increases in TNFα, IL-1β, and receptor activator of NF-κB ligand (RANKL). Anti-IL-1 or anti-TNFα therapies consistently reduce inflammation in these models, but systemic bone loss o...

Descripción completa

Detalles Bibliográficos
Autores principales: Stolina, Marina, Schett, Georg, Dwyer, Denise, Vonderfecht, Steven, Middleton, Scot, Duryea, Diane, Pacheco, Efrain, Van, Gwyneth, Bolon, Brad, Feige, Ulrich, Zack, Debra, Kostenuik, Paul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003514/
https://www.ncbi.nlm.nih.gov/pubmed/20003323
http://dx.doi.org/10.1186/ar2879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003514/
https://www.ncbi.nlm.nih.gov/pubmed/20003323
http://dx.doi.org/10.1186/ar2879

Ejemplares similares