Functional Genetic Variants that Increase Synaptic Serotonin and 5-HT3 Receptor Sensitivity Predict Alcohol and Drug Dependence

The 5-HT3 receptor is rapidly potentiated by ethanol and mediates fast excitatory 5-HT transmission that modulates dopamine release in the reward circuitry. The 5-HT transporter regulates synaptic 5-HT availability. Functional polymorphisms in genes encoding the transporter and receptor may therefor...

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Detalles Bibliográficos
Autores principales: Enoch, Mary-Anne, Gorodetsky, Elena, Hodgkinson, Colin, Roy, Alec, Goldman, David
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003772/
https://www.ncbi.nlm.nih.gov/pubmed/20838391
http://dx.doi.org/10.1038/mp.2010.94

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003772/
https://www.ncbi.nlm.nih.gov/pubmed/20838391
http://dx.doi.org/10.1038/mp.2010.94

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