Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain, neuronal cell loss and cognitive decline. We show here that retinoic acid receptor (RAR)α signalling in vitro can prevent both intracellular and extracellular Aβ accumulation. RARα signalling increases the expressio...

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Detalles Bibliográficos
Autores principales: Jarvis, C I, Goncalves, M B, Clarke, E, Dogruel, M, Kalindjian, S B, Thomas, S A, Maden, M, Corcoran, J P T
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Molecular and Developmental Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003897/
https://www.ncbi.nlm.nih.gov/pubmed/20950278
http://dx.doi.org/10.1111/j.1460-9568.2010.07426.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003897/
https://www.ncbi.nlm.nih.gov/pubmed/20950278
http://dx.doi.org/10.1111/j.1460-9568.2010.07426.x

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