Opioid chronopharmacology: influence of timing of infusion on fentanyl’s analgesic efficacy in healthy human volunteers

Chronopharmacology studies the effect of the timing of drug administration on drug effect. Here, we measured the influence of 4 timing moments on fentanyl-induced antinociception in healthy volunteers. Eight subjects received 2.1 μg/kg intravenous fentanyl at 2 pm and 2 am, with at least 2 weeks bet...

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Detalles Bibliográficos
Autores principales: Boom, Merel, Grefkens, Joost, van Dorp, Eveline, Olofsen, Erik, Lourenssen, Gertjan, Aarts, Leon, Dahan, Albert, Sarton, Elise
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004635/
https://www.ncbi.nlm.nih.gov/pubmed/21197322
http://dx.doi.org/10.2147/JPR.S13616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004635/
https://www.ncbi.nlm.nih.gov/pubmed/21197322
http://dx.doi.org/10.2147/JPR.S13616

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