Classification of Drugs Based on Properties of Sodium Channel Inhibition: A Comparative Automated Patch-Clamp Study

BACKGROUND: There is only one established drug binding site on sodium channels. However, drug binding of sodium channels shows extreme promiscuity: ∼25% of investigated drugs have been found to potently inhibit sodium channels. The structural diversity of these molecules suggests that they may not s...

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Detalles Bibliográficos
Autores principales: Lenkey, Nora, Karoly, Robert, Lukacs, Peter, Vizi, E. Sylvester, Sunesen, Morten, Fodor, Laszlo, Mike, Arpad
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004914/
https://www.ncbi.nlm.nih.gov/pubmed/21187965
http://dx.doi.org/10.1371/journal.pone.0015568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004914/
https://www.ncbi.nlm.nih.gov/pubmed/21187965
http://dx.doi.org/10.1371/journal.pone.0015568

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