A family history of DUX4: phylogenetic analysis of DUXA, B, C and Duxbl reveals the ancestral DUX gene

BACKGROUND: DUX4 is causally involved in the molecular pathogenesis of the neuromuscular disorder facioscapulohumeral muscular dystrophy (FSHD). It has previously been proposed to have arisen by retrotransposition of DUXC, one of four known intron-containing DUX genes. Here, we investigate the evolu...

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Detalles Bibliográficos
Autores principales: Leidenroth, Andreas, Hewitt, Jane E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004920/
https://www.ncbi.nlm.nih.gov/pubmed/21110847
http://dx.doi.org/10.1186/1471-2148-10-364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004920/
https://www.ncbi.nlm.nih.gov/pubmed/21110847
http://dx.doi.org/10.1186/1471-2148-10-364

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