Cargando…

Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation

BACKGROUND: Widespread resistance of the main malaria vector Anopheles gambiae to pyrethroids reported in many African countries and operational drawbacks to current IRS methods suggest the convenience of exploring new products and approaches for vector control. Insecticide paint Inesfly 5A IGR™, co...

Descripción completa

Detalles Bibliográficos
Autores principales: Mosqueira, Beatriz, Chabi, Joseph, Chandre, Fabrice, Akogbeto, Martin, Hougard, Jean-Marc, Carnevale, Pierre, Mas-Coma, Santiago
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004939/
https://www.ncbi.nlm.nih.gov/pubmed/21108820
http://dx.doi.org/10.1186/1475-2875-9-341
_version_ 1782194059414077440
author Mosqueira, Beatriz
Chabi, Joseph
Chandre, Fabrice
Akogbeto, Martin
Hougard, Jean-Marc
Carnevale, Pierre
Mas-Coma, Santiago
author_facet Mosqueira, Beatriz
Chabi, Joseph
Chandre, Fabrice
Akogbeto, Martin
Hougard, Jean-Marc
Carnevale, Pierre
Mas-Coma, Santiago
author_sort Mosqueira, Beatriz
collection PubMed
description BACKGROUND: Widespread resistance of the main malaria vector Anopheles gambiae to pyrethroids reported in many African countries and operational drawbacks to current IRS methods suggest the convenience of exploring new products and approaches for vector control. Insecticide paint Inesfly 5A IGR™, containing two organophosphates (OPs), chlorpyrifos and diazinon, and one insect growth regulator (IGR), pyriproxyfen, was tested in Benin, West Africa, for 12 months. METHODS: Field trials were conducted in six experimental huts that were randomly allocated to one or two layers of insecticide at 1 Kg/6 m(2 )or control. Evaluations included: (i) early mosquito collection, (ii) mosquito release experiments, (iii) residual efficacy tests and (iv) distance tests. Early mosquito collections were performed on local populations of pyrethroid-resistant An. gambiae and Culex quinquefasciatus. As per WHOPES phase II procedures, four entomological criteria were evaluated: deterrence, excito-repellence, blood-feeding inhibition and mortality. Mosquito release experiments were done using local malaria-free An. gambiae females reared at the CREC insectarium. Residual efficacy tests and distance tests were performed using reference susceptible strains of An. gambiae and Cx. quinquefasciatus. RESULTS: Six months after treatment, mortality rates were still 90-100% against pyrethroid-resistant mosquito populations in experimental huts. At nine months, mortality rates in huts treated with two layers was still about 90-93% against An. gambiae and 55% against Cx. quinquefasciatus. Malaria-free local mosquito release experiments yielded a 90% blood-feeding inhibition in the absence of a physical barrier. A long-term residual efficacy of 12 months was observed by WHO-bioassays in huts treated with two layers (60-80%). Mortality after an overnight exposition at distances of 1 meter was 96-100% for up to 12 months. CONCLUSION: The encouraging results obtained on the insecticide paint Inesfly 5A IGR™ in terms of mortality, be it in direct contact or at a distance, and its new operational approach could constitute an additional option in malaria control efforts in areas of pyrethroid resistance. Phase III studies will be performed to assess the product's epidemiological impact and sociological acceptance.
format Text
id pubmed-3004939
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30049392010-12-21 Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation Mosqueira, Beatriz Chabi, Joseph Chandre, Fabrice Akogbeto, Martin Hougard, Jean-Marc Carnevale, Pierre Mas-Coma, Santiago Malar J Research BACKGROUND: Widespread resistance of the main malaria vector Anopheles gambiae to pyrethroids reported in many African countries and operational drawbacks to current IRS methods suggest the convenience of exploring new products and approaches for vector control. Insecticide paint Inesfly 5A IGR™, containing two organophosphates (OPs), chlorpyrifos and diazinon, and one insect growth regulator (IGR), pyriproxyfen, was tested in Benin, West Africa, for 12 months. METHODS: Field trials were conducted in six experimental huts that were randomly allocated to one or two layers of insecticide at 1 Kg/6 m(2 )or control. Evaluations included: (i) early mosquito collection, (ii) mosquito release experiments, (iii) residual efficacy tests and (iv) distance tests. Early mosquito collections were performed on local populations of pyrethroid-resistant An. gambiae and Culex quinquefasciatus. As per WHOPES phase II procedures, four entomological criteria were evaluated: deterrence, excito-repellence, blood-feeding inhibition and mortality. Mosquito release experiments were done using local malaria-free An. gambiae females reared at the CREC insectarium. Residual efficacy tests and distance tests were performed using reference susceptible strains of An. gambiae and Cx. quinquefasciatus. RESULTS: Six months after treatment, mortality rates were still 90-100% against pyrethroid-resistant mosquito populations in experimental huts. At nine months, mortality rates in huts treated with two layers was still about 90-93% against An. gambiae and 55% against Cx. quinquefasciatus. Malaria-free local mosquito release experiments yielded a 90% blood-feeding inhibition in the absence of a physical barrier. A long-term residual efficacy of 12 months was observed by WHO-bioassays in huts treated with two layers (60-80%). Mortality after an overnight exposition at distances of 1 meter was 96-100% for up to 12 months. CONCLUSION: The encouraging results obtained on the insecticide paint Inesfly 5A IGR™ in terms of mortality, be it in direct contact or at a distance, and its new operational approach could constitute an additional option in malaria control efforts in areas of pyrethroid resistance. Phase III studies will be performed to assess the product's epidemiological impact and sociological acceptance. BioMed Central 2010-11-25 /pmc/articles/PMC3004939/ /pubmed/21108820 http://dx.doi.org/10.1186/1475-2875-9-341 Text en Copyright ©2010 Mosqueira et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Mosqueira, Beatriz
Chabi, Joseph
Chandre, Fabrice
Akogbeto, Martin
Hougard, Jean-Marc
Carnevale, Pierre
Mas-Coma, Santiago
Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation
title Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation
title_full Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation
title_fullStr Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation
title_full_unstemmed Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation
title_short Efficacy of an insecticide paint against malaria vectors and nuisance in West Africa - Part 2: Field evaluation
title_sort efficacy of an insecticide paint against malaria vectors and nuisance in west africa - part 2: field evaluation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004939/
https://www.ncbi.nlm.nih.gov/pubmed/21108820
http://dx.doi.org/10.1186/1475-2875-9-341
work_keys_str_mv AT mosqueirabeatriz efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation
AT chabijoseph efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation
AT chandrefabrice efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation
AT akogbetomartin efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation
AT hougardjeanmarc efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation
AT carnevalepierre efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation
AT mascomasantiago efficacyofaninsecticidepaintagainstmalariavectorsandnuisanceinwestafricapart2fieldevaluation