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Clearance (née Rowland) concepts: a downdate and an update
A number of experimental observations in the late 1960s, early 1970s could not be explained by the pharmacokinetic theory available at that time. For example rats receiving phenobarbital as an enzyme inducing agent exhibited increased elimination of phenylbutazone in vitro in liver microsomes and in...
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| Formato: | Texto |
| Lenguaje: | English |
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Springer US
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005114/ https://www.ncbi.nlm.nih.gov/pubmed/21113650 http://dx.doi.org/10.1007/s10928-010-9187-8 |