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An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots

Clotting blood contains fibrin-bound thrombin, which is a major source of procoagulant activity leading to clot extension and further activation of coagulation. When bound to fibrin, thrombin is protected from inhibition by antithrombin (AT) + heparin but is neutralized when AT and heparin are coval...

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Detalles Bibliográficos
Autores principales: Smith, Lesley J., Mewhort-Buist, Tracy Anne, Berry, Leslie R., Chan, Anthony K. C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005802/
https://www.ncbi.nlm.nih.gov/pubmed/22820671
http://dx.doi.org/10.1155/2008/639829
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author Smith, Lesley J.
Mewhort-Buist, Tracy Anne
Berry, Leslie R.
Chan, Anthony K. C.
author_facet Smith, Lesley J.
Mewhort-Buist, Tracy Anne
Berry, Leslie R.
Chan, Anthony K. C.
author_sort Smith, Lesley J.
collection PubMed
description Clotting blood contains fibrin-bound thrombin, which is a major source of procoagulant activity leading to clot extension and further activation of coagulation. When bound to fibrin, thrombin is protected from inhibition by antithrombin (AT) + heparin but is neutralized when AT and heparin are covalently linked (ATH). Here, we report the surprising observation that, rather than yielding an inert complex, thrombin-ATH formation converts clots into anticoagulant surfaces that effectively catalyze inhibition of thrombin in the surrounding environment.
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spelling pubmed-30058022010-12-23 An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots Smith, Lesley J. Mewhort-Buist, Tracy Anne Berry, Leslie R. Chan, Anthony K. C. Res Lett Biochem Research Letter Clotting blood contains fibrin-bound thrombin, which is a major source of procoagulant activity leading to clot extension and further activation of coagulation. When bound to fibrin, thrombin is protected from inhibition by antithrombin (AT) + heparin but is neutralized when AT and heparin are covalently linked (ATH). Here, we report the surprising observation that, rather than yielding an inert complex, thrombin-ATH formation converts clots into anticoagulant surfaces that effectively catalyze inhibition of thrombin in the surrounding environment. Hindawi Publishing Corporation 2008 2008-04-14 /pmc/articles/PMC3005802/ /pubmed/22820671 http://dx.doi.org/10.1155/2008/639829 Text en Copyright © 2008 Lesley J. Smith et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Letter
Smith, Lesley J.
Mewhort-Buist, Tracy Anne
Berry, Leslie R.
Chan, Anthony K. C.
An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
title An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
title_full An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
title_fullStr An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
title_full_unstemmed An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
title_short An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
title_sort antithrombin-heparin complex increases the anticoagulant activity of fibrin clots
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005802/
https://www.ncbi.nlm.nih.gov/pubmed/22820671
http://dx.doi.org/10.1155/2008/639829
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