Two Distantly Spaced Basic Patches in the Flexible Domain of Huntingtin-Interacting Protein 1 (HIP1) Are Essential for the Binding of Clathrin Light Chain

The interaction between HIP family proteins (HIP1 and HIP12/1R) and clathrin is fundamental to endocytosis. We used circular dichroism (CD) to study the stability of an HIP1 subfragment (aa468-530) that is splayed open. CD thermal melts show HIP1 468-530 is only stable at low temperatures, but this...

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Detalles Bibliográficos
Autores principales: Ybe, Joel A., Clegg, Mary E., Illingworth, Melissa, Gonzalez, Claire, Niu, Qian
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005887/
https://www.ncbi.nlm.nih.gov/pubmed/22820750
http://dx.doi.org/10.1155/2009/256124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005887/
https://www.ncbi.nlm.nih.gov/pubmed/22820750
http://dx.doi.org/10.1155/2009/256124

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