mTORC1-S6K Activation by Endotoxin Contributes to Cytokine Up-Regulation and Early Lethality in Animals

BACKGROUND: mTORC1 (mammalian target of rapamycin complex 1) activation has been demonstrated in response to endotoxin challenge, but the mechanism and significance are unclear. We investigated the effect of mTORC1 suppression in an animal model of endotoxemia and in a cellular model of endotoxin si...

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Detalles Bibliográficos
Autores principales: Lee, Po-Shun, Wilhelmson, Anna S. K., Hubner, Anton P., Reynolds, Samuel B., Gallacchi, Dana A., Chiou, Terry T., Kwiatkowski, David J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006197/
https://www.ncbi.nlm.nih.gov/pubmed/21200439
http://dx.doi.org/10.1371/journal.pone.0014399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006197/
https://www.ncbi.nlm.nih.gov/pubmed/21200439
http://dx.doi.org/10.1371/journal.pone.0014399

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