Diphthamide biosynthesis requires an Fe-S enzyme-generated organic radical

Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called “diphthamide”, the target of diphtheria toxin. The biosynthesis of diphthamide were proposed to involve three steps, with the first step being the formation of a C-C bond be...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yang, Zhu, Xuling, Torelli, Andrew T., Lee, Michael, Dzikovski, Boris, Koralewski, Rachel M., Wang, Eileen, Freed, Jack, Krebs, Carsten, Ealick, Steven E., Lin, Hening
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006227/
https://www.ncbi.nlm.nih.gov/pubmed/20559380
http://dx.doi.org/10.1038/nature09138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006227/
https://www.ncbi.nlm.nih.gov/pubmed/20559380
http://dx.doi.org/10.1038/nature09138

Ejemplares similares