HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

Herceptin (trastuzumab) is used in patients with breast cancer who have HER2 (ErbB2)–positive tumours. However, its mechanisms of action and how acquired resistance to Herceptin occurs are still poorly understood. It was previously thought that the anti-HER2 monoclonal antibody Herceptin inhibits HE...

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Detalles Bibliográficos
Autores principales: Gijsen, Merel, King, Peter, Perera, Tim, Parker, Peter J., Harris, Adrian L., Larijani, Banafshé, Kong, Anthony
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006345/
https://www.ncbi.nlm.nih.gov/pubmed/21203579
http://dx.doi.org/10.1371/journal.pbio.1000563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006345/
https://www.ncbi.nlm.nih.gov/pubmed/21203579
http://dx.doi.org/10.1371/journal.pbio.1000563

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