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Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice via S1P(1) receptor activation

Liver failure due to ischemia and reperfusion (IR) and subsequent acute kidney injury are significant clinical problems. We showed previously that liver IR selectively reduced plasma sphinganine-1-phosphate levels without affecting sphingosine 1-phosphate (S1P) levels. Furthermore, exogenous sphinga...

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Detalles Bibliográficos
Autores principales: Park, Sang Won, Kim, Mihwa, Chen, Sean W. C., Brown, Kevin M., D’Agati, Vivette D., Lee, H. Thomas
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007623/
https://www.ncbi.nlm.nih.gov/pubmed/20458275
http://dx.doi.org/10.1038/labinvest.2010.102