A Novel HMM-Based Method for Detecting Enriched Transcription Factor Binding Sites Reveals RUNX3 as a Potential Target in Pancreatic Cancer Biology

BACKGROUND: Pancreatic adenocarcinoma (PAC) is one of the most intractable malignancies. In order to search for potential new therapeutic targets, we relied on computational methods aimed at identifying transcription factor binding sites (TFBSs) over-represented in the promoter regions of genes diff...

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Detalles Bibliográficos
Autores principales: Levkovitz, Liron, Yosef, Nir, Gershengorn, Marvin C., Ruppin, Eytan, Sharan, Roded, Oron, Yoram
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008686/
https://www.ncbi.nlm.nih.gov/pubmed/21203558
http://dx.doi.org/10.1371/journal.pone.0014423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008686/
https://www.ncbi.nlm.nih.gov/pubmed/21203558
http://dx.doi.org/10.1371/journal.pone.0014423

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