Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice

A strain of human CD3ε transgenic mice, tgε26, exhibits severe immunodeficiency associated with early arrest of T cell development. Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohigashi, Izumi, Yamasaki, Yuki, Hirashima, Tsukasa, Takahama, Yousuke
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008721/
https://www.ncbi.nlm.nih.gov/pubmed/21203507
http://dx.doi.org/10.1371/journal.pone.0014391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008721/
https://www.ncbi.nlm.nih.gov/pubmed/21203507
http://dx.doi.org/10.1371/journal.pone.0014391

Ejemplares similares