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Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice
A strain of human CD3ε transgenic mice, tgε26, exhibits severe immunodeficiency associated with early arrest of T cell development. Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008721/ https://www.ncbi.nlm.nih.gov/pubmed/21203507 http://dx.doi.org/10.1371/journal.pone.0014391 |