LIF independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

Activating mutations in the tyrosine kinase JAK2 cause myeloproliferative neoplasms, clonal blood stem cell disorders with a propensity for leukaemic transformation. LIF signalling through JAK-STAT enables ES cell self-renewal. Here we show that mouse ES cells carrying the human JAK2V617F mutation c...

Descripción completa

Detalles Bibliográficos
Autores principales: Griffiths, Dean S., Li, Juan, Dawson, Mark A., Trotter, Matthew W.B., Cheng, Yi-Han, Smith, Aileen M., Mansfield, William, Liu, Pentao, Kouzarides, Tony, Nichols, Jennifer, Bannister, Andrew J., Green, Anthony R, Göttgens, Berthold
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008749/
https://www.ncbi.nlm.nih.gov/pubmed/21151131
http://dx.doi.org/10.1038/ncb2135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008749/
https://www.ncbi.nlm.nih.gov/pubmed/21151131
http://dx.doi.org/10.1038/ncb2135

Ejemplares similares