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The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma

BACKGROUND: Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-domain transcription factors. The PEA3 subfamily of ETS-d...

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Detalles Bibliográficos
Autores principales: Keld, Richard, Guo, Baoqiang, Downey, Paul, Gulmann, Christian, Ang, Yeng S, Sharrocks, Andrew D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009708/
https://www.ncbi.nlm.nih.gov/pubmed/21143918
http://dx.doi.org/10.1186/1476-4598-9-313