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Unregulated miR-96 Induces Cell Proliferation in Human Breast Cancer by Downregulating Transcriptional Factor FOXO3a

FOXO transcription factors are key tumor suppressors in mammalian cells. Until now, suppression of FOXOs in cancer cells was thought to be mainly due to activation of multiple onco-kinases by a phosphorylation-ubiquitylation-mediated cascade. Therefore, it was speculated that inhibition of FOXO prot...

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Detalles Bibliográficos
Autores principales: Lin, Huanxin, Dai, Ting, Xiong, Huaping, Zhao, Xiaohui, Chen, Xiuting, Yu, Chunping, Li, Jun, Wang, Xi, Song, Libing
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009749/
https://www.ncbi.nlm.nih.gov/pubmed/21203424
http://dx.doi.org/10.1371/journal.pone.0015797