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Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain
BACKGROUND: The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly understood. In this study, in vitro and in vivo ph...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009975/ https://www.ncbi.nlm.nih.gov/pubmed/21143971 http://dx.doi.org/10.1186/1744-8069-6-90 |