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Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

BACKGROUND: The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly understood. In this study, in vitro and in vivo ph...

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Detalles Bibliográficos
Autores principales: Serrano, Alexandre, Paré, Michel, McIntosh, Fraser, Elmes, Steven JR, Martino, Giovanni, Jomphe, Claudia, Lessard, Etienne, Lembo, Paola MC, Vaillancourt, François, Perkins, Martin N, Cao, Chang Qing
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009975/
https://www.ncbi.nlm.nih.gov/pubmed/21143971
http://dx.doi.org/10.1186/1744-8069-6-90