Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

BACKGROUND: The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly understood. In this study, in vitro and in vivo ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Serrano, Alexandre, Paré, Michel, McIntosh, Fraser, Elmes, Steven JR, Martino, Giovanni, Jomphe, Claudia, Lessard, Etienne, Lembo, Paola MC, Vaillancourt, François, Perkins, Martin N, Cao, Chang Qing
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009975/
https://www.ncbi.nlm.nih.gov/pubmed/21143971
http://dx.doi.org/10.1186/1744-8069-6-90

Ejemplares similares

Ejemplares similares