Culling sick mitochondria from the herd

The PINK1–Parkin pathway plays a critical role in mitochondrial quality control by selectively targeting damaged mitochondria for autophagy. In this issue, Tanaka et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201007013) demonstrate that the AAA-type ATPase p97 acts downstream of PINK1 and Parkin to s...

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Detalles Bibliográficos
Autor principal: Pallanck, Leo J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010062/
https://www.ncbi.nlm.nih.gov/pubmed/21187326
http://dx.doi.org/10.1083/jcb.201011068
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author Pallanck, Leo J.
author_facet Pallanck, Leo J.
author_sort Pallanck, Leo J.
collection PubMed
description The PINK1–Parkin pathway plays a critical role in mitochondrial quality control by selectively targeting damaged mitochondria for autophagy. In this issue, Tanaka et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201007013) demonstrate that the AAA-type ATPase p97 acts downstream of PINK1 and Parkin to segregate fusion-incompetent mitochondria for turnover. p97 acts by targeting the mitochondrial fusion-promoting factor mitofusin for degradation through an endoplasmic reticulum–associated degradation (ERAD)-like mechanism.
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spelling pubmed-30100622011-06-27 Culling sick mitochondria from the herd Pallanck, Leo J. J Cell Biol Reviews The PINK1–Parkin pathway plays a critical role in mitochondrial quality control by selectively targeting damaged mitochondria for autophagy. In this issue, Tanaka et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201007013) demonstrate that the AAA-type ATPase p97 acts downstream of PINK1 and Parkin to segregate fusion-incompetent mitochondria for turnover. p97 acts by targeting the mitochondrial fusion-promoting factor mitofusin for degradation through an endoplasmic reticulum–associated degradation (ERAD)-like mechanism. The Rockefeller University Press 2010-12-27 /pmc/articles/PMC3010062/ /pubmed/21187326 http://dx.doi.org/10.1083/jcb.201011068 Text en © 2010 Pallanck This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Pallanck, Leo J.
Culling sick mitochondria from the herd
title Culling sick mitochondria from the herd
title_full Culling sick mitochondria from the herd
title_fullStr Culling sick mitochondria from the herd
title_full_unstemmed Culling sick mitochondria from the herd
title_short Culling sick mitochondria from the herd
title_sort culling sick mitochondria from the herd
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010062/
https://www.ncbi.nlm.nih.gov/pubmed/21187326
http://dx.doi.org/10.1083/jcb.201011068
work_keys_str_mv AT pallanckleoj cullingsickmitochondriafromtheherd

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