SIRT1 contributes to telomere maintenance and augments global homologous recombination

Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex spreads into subtelomeric DNA via histone deacetylation. However, potential functions at telomeres for SIRT1, the mammali...

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Detalles Bibliográficos
Autores principales: Palacios, Jose A., Herranz, Daniel, De Bonis, Maria Luigia, Velasco, Susana, Serrano, Manuel, Blasco, Maria A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010065/
https://www.ncbi.nlm.nih.gov/pubmed/21187328
http://dx.doi.org/10.1083/jcb.201005160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010065/
https://www.ncbi.nlm.nih.gov/pubmed/21187328
http://dx.doi.org/10.1083/jcb.201005160

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