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HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells

In contrast to somatic cells, formation of acentriolar meiotic spindles relies on the organization of microtubules (MTs) and MT-organizing centers (MTOCs) into a stable bipolar structure. The underlying mechanisms are still unknown. We show that this process is impaired in hepatoma up-regulated prot...

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Detalles Bibliográficos
Autores principales: Breuer, Manuel, Kolano, Agnieszka, Kwon, Mijung, Li, Chao-Chin, Tsai, Ting-Fen, Pellman, David, Brunet, Stéphane, Verlhac, Marie-Hélène
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010075/
https://www.ncbi.nlm.nih.gov/pubmed/21173113
http://dx.doi.org/10.1083/jcb.201005065