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Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis

Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic pathwa...

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Detalles Bibliográficos
Autores principales: Kim, Juhan, Kershner, Jamie P, Novikov, Yehor, Shoemaker, Richard K, Copley, Shelley D
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010111/
https://www.ncbi.nlm.nih.gov/pubmed/21119630
http://dx.doi.org/10.1038/msb.2010.88