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ER Stress and Iron Homeostasis: A New Frontier for the UPR
The C282Y mutation of HFE accounts for the majority of cases of the iron overload disease Hereditary Hemochromatosis (HH). The conformational changes introduced by this mutation impair the HFE association with β (2)-microglobulin (β (2)m) and the cell surface expression of the protein: with two majo...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010616/ https://www.ncbi.nlm.nih.gov/pubmed/21197476 http://dx.doi.org/10.1155/2011/896474 |