An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome

People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt(5−8), in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this poly...

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Detalles Bibliográficos
Autores principales: Jones, Emma L., Ballard, Clive G., Prasher, Vee P., Arno, Matthew, Tyrer, Stephen, Moore, Brian, Hanney, Maria Luisa
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010675/
https://www.ncbi.nlm.nih.gov/pubmed/21197396
http://dx.doi.org/10.4061/2011/929102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010675/
https://www.ncbi.nlm.nih.gov/pubmed/21197396
http://dx.doi.org/10.4061/2011/929102

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