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An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome
People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt(5−8), in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this poly...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
SAGE-Hindawi Access to Research
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010675/ https://www.ncbi.nlm.nih.gov/pubmed/21197396 http://dx.doi.org/10.4061/2011/929102 |