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CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy
Intracellular reduced folate exists as a “pool” of more than 6 interconvertable forms. One of these forms, 5,10 methylenetetrahydrofolic acid (CH(2)THF), is the key one-carbon donor and reduced folate substrate for thymidylate synthase (TS). This pathway has been an important target for chemotherapy...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010680/ https://www.ncbi.nlm.nih.gov/pubmed/21209714 http://dx.doi.org/10.1155/2010/934359 |