PGE(2) Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy

BACKGROUND: IL-6 plays an important role in the pathogenesis of Graves' disease and its orbital component, thyroid-associated ophthalmopathy (TAO). Orbital tissues become inflamed in TAO, a process in which prostanoids have been implicated. Orbital fibroblasts both generate and respond to PGE(2...

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Detalles Bibliográficos
Autores principales: Raychaudhuri, Nupur, Douglas, Raymond S., Smith, Terry J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011019/
https://www.ncbi.nlm.nih.gov/pubmed/21209948
http://dx.doi.org/10.1371/journal.pone.0015296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011019/
https://www.ncbi.nlm.nih.gov/pubmed/21209948
http://dx.doi.org/10.1371/journal.pone.0015296

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